Jump to content

Recommended Posts

Hi Peter,

you say denying patients access to D3 to enable a good quality RCT  is immoral.

However the Govt's around the world are denying access to ALL their populations by simply ignoring the practical stats.

Scientific studies are long drawn out exercises and as you say may deny access here and there for a very long time.

Thus as D3 is quite 'harmless'  and may be a cheap moderator to the virus then surely any Govt would be mad not to try it on a national scale.

 

Roger

 

 

Link to post
Share on other sites
  • Replies 1.9k
  • Created
  • Last Reply

Top Posters In This Topic

Top Posters In This Topic

Popular Posts

HELP THE NHS ~ I've let my adjoining empty house (fully furnished) to four NHS nurses free of charge during this National Emergency. We have a very large General Hospital at the top of the r

Very very Harsh Geko. I see a man, in an unenviable position, doing his utmost to balance the impossible tasks of trying to control the spread of a new novel virus - for which there is no treatme

By the book...

Posted Images

9 minutes ago, RogerH said:

Hi Peter,

you say denying patients access to D3 to enable a good quality RCT  is immoral.

However the Govt's around the world are denying access to ALL their populations by simply ignoring the practical stats.

Scientific studies are long drawn out exercises and as you say may deny access here and there for a very long time.

Thus as D3 is quite 'harmless'  and may be a cheap moderator to the virus then surely any Govt would be mad not to try it on a national scale.

 

Roger

 

 

Roger, D3 has been ignored long before coronavirus by all but a minority of clinicians. In UK, USA etc decision making was handed to expert cttees who knew about D3 for bone. So dose was (and is) based upon bone. Science has revealed D3 afffects a host of other conditions (see vitamindwiki) that small studies show pts responding to higher D3 doses. But these RCTs were deemed too small to be convincing. And big RCTs cost millions and there's no profit in D3 to pay for them. And so the tragedy plays out.

Yes I think the gov is mad not to advise more than bone-health doses. They do advise 400 ( or 800 for BAME and those lacking summer sun) but its not enough, but does cover them from claims.Has anyone on here seen that advcie advertised like hand-washing, distancing etc ? I haven't.

Peter

Link to post
Share on other sites

Last evening BBC East Midlands Today showed a short report on the potential benefits of D3 supplements for the BAME community to reduce the severity of COVID-19. The story came from the Royal Derby Hospital where 4 members of staff died as a result of C-19. There were all from the BAME community. As a result of that, RDH are now encouraging all their BAME staff to take vitamin D3 supplements and making them available for free.  They did not state the dose but showed an image of a 25mcg bottle.

Another small step for mankind.

Mick

Link to post
Share on other sites
9 minutes ago, Mick Forey said:

Last evening BBC East Midlands Today showed a short report on the potential benefits of D3

Hi Mick. Was that early evening or late evening? I just skimmed through and couldn't find it.

Cheers, Richard

Link to post
Share on other sites
2 hours ago, Mick Forey said:

Last evening BBC East Midlands Today showed a short report on the potential benefits of D3 supplements for the BAME community to reduce the severity of COVID-19. The story came from the Royal Derby Hospital where 4 members of staff died as a result of C-19. There were all from the BAME community. As a result of that, RDH are now encouraging all their BAME staff to take vitamin D3 supplements and making them available for free.  They did not state the dose but showed an image of a 25mcg bottle.

Another small step for mankind.

Mick

Thanks Mick, useful to know, I'pass it on to David Grimes. Peter

Link to post
Share on other sites
14 hours ago, barkerwilliams said:

Thanks Alan, That finding might not apply to UK as milk is fortified in USA and maybe other foods. UK diet IIRC supplies around 150IU pd, miserably low.

Peter

Link to post
Share on other sites
Just now, Peter Cobbold said:

Thanks Alan, That finding might not apply to UK as milk is fortified in USA and maybe other foods. UK diet IIRC supplies around 150IU pd, miserably low.

Since starting on D3 I found my memory for names is much sharper nowadays. Fingers crossed it will help.

Peter

 

Link to post
Share on other sites
24 minutes ago, barkerwilliams said:

Alan, Thanks, a new angle.

Heparan sulphate acts as a  trigger for inflammetion, by activating Toll-like receptors.https://www.ingentaconnect.com/contentone/ben/mrmc/2017/00000017/00000006/art00005?crawler=true&mimetype=application/pdf 

HS is destroyed by heparanase an enzyme whose expression is inhibited by D3: https://onlinelibrary.wiley.com/doi/pdf/10.1002/path.4639

So in D3 deficiency heparanase will be higher and hence HS lower with a consequent reduction in TLR activation and less inflammation.

At first sight this would suggest that boosting D3 makes inflammation worse ! However D3 will act to raise HS levels and as the authors comment:

image.png.d2d31f04ca8b1ffd7578711ec9d03f82.png

I surmise that raising D3 will supress heparanase, raise HS and compete-off the virus form membrane-bound ACE2.

But I could be wrong. However D3 definitely reduces expression of ACE2 so , and that is mandatory for virus entry, I reckon 500m years of D3 evolution is still likely to be right.

Peter

 

 

Link to post
Share on other sites
7 minutes ago, Peter Cobbold said:

Cordoba "noted".............then relegated to the round file of SACN.

https://questions-statements.parliament.uk/written-questions/detail/2020-09-14/89623

Peter

Hi Peter,

I have a bucket of sand going spare for these people to stick their heads in.

However I would suggest that there is no overwhelming evidence that a bucket of sand would be of any use.

 

Roger

Link to post
Share on other sites

One US politician is on the money

https://grothman.house.gov/news/documentsingle.aspx?DocumentID=1777

With Fauci taking D3 ( supposedly 6000 IU pd) it cannot be long before the story breaks across the US meedja and in then globally.

Peter

Link to post
Share on other sites
4 hours ago, Peter Cobbold said:

One US politician is on the money

https://grothman.house.gov/news/documentsingle.aspx?DocumentID=1777

With Fauci taking D3 ( supposedly 6000 IU pd) it cannot be long before the story breaks across the US meedja and in then globally.

Peter

 

Haven't heard a peep about D3 in the public press here, Peter.  It's a long way from breaking into public consciousness in the USA, I'd say.  With all the BS running wild in the run up to our election, there's probably no chance for Facui's supplement program to make it through the din.

Plus with all the misinformation about other magical treatments (read hydroxychloroquine and certain science-denying people in government and press), it's going to be hard to get Americans to believe in anything right now.

That said, I'm at 6000 IU/day D3, too.

Link to post
Share on other sites
17 minutes ago, Don H. said:

 

Haven't heard a peep about D3 in the public press here, Peter.  It's a long way from breaking into public consciousness in the USA, I'd say.  With all the BS running wild in the run up to our election, there's probably no chance for Facui's supplement program to make it through the din.

Plus with all the misinformation about other magical treatments (read hydroxychloroquine and certain science-denying people in government and press), it's going to be hard to get Americans to believe in anything right now.

That said, I'm at 6000 IU/day D3, too.

Hi Don,  

I'm now on 4000. Tried 10,000 for most of year but got hints of calciurea ( I was taking whey supplements too and that added 1 gram extra Ca to diet).

Looks like virus is mutating its spike protein fast, and before any  vaccines targeting the spike are in use:

https://www.medrxiv.org/content/10.1101/2020.09.22.20199125v1

Am increasingly confident D3 will come to the rescue, problem is when ? and will stocks last?

Peter

Link to post
Share on other sites
24 minutes ago, Don H. said:

 

Haven't heard a peep about D3 in the public press here, Peter.  It's a long way from breaking into public consciousness in the USA, I'd say.  With all the BS running wild in the run up to our election, there's probably no chance for Facui's supplement program to make it through the din.

Plus with all the misinformation about other magical treatments (read hydroxychloroquine and certain science-denying people in government and press), it's going to be hard to get Americans to believe in anything right now.

That said, I'm at 6000 IU/day D3, too.

As a family we have taken vitamin D3 and Omega fish oil capsules daily for a number of years. It’s difficult to quantify it’s effectiveness for the average Joe, unless you conduct scientific tests.

Its a bit like asking someone how many times he hasn’t had an accident due to wearing a hi-viz jacket. I do however believe the vitamin is effective, as long as we treat the rest of our health seriously, as it is the robustness of our immune system as a whole, and not just a vitamin which might protect us from any viral attacks.

Kevin  

Link to post
Share on other sites
22 minutes ago, boxofbits said:

As a family we have taken vitamin D3 and Omega fish oil capsules daily for a number of years. It’s difficult to quantify it’s effectiveness for the average Joe, unless you conduct scientific tests.

Its a bit like asking someone how many times he hasn’t had an accident due to wearing a hi-viz jacket. I do however believe the vitamin is effective, as long as we treat the rest of our health seriously, as it is the robustness of our immune system as a whole, and not just a vitamin which might protect us from any viral attacks.

Kevin  

My regular Dr (an internal medicine specialist) recommended D3 supplements to me years ago due to a family history of osteoporosis and my test results.  The stuff around coronavirus is very nice to know, but isn't why I started on D3.  I think the link between D3 and calcium uptake is well proven.

One of my former colleagues, a research fellow in what might be the leading company making soy protein isolates, was quite convinced after his extensive study of the literature that Omega fish oils had a beneficial effect on inflammation.  He was unambiguous in his conclusions that they were worth taking.  'Course, that was 10-15 years ago now and we probably know a lot more and I'm not up to date on the latest work.

Link to post
Share on other sites
17 minutes ago, boxofbits said:

As a family we have taken vitamin D3 and Omega fish oil capsules daily for a number of years. It’s difficult to quantify it’s effectiveness for the average Joe, unless you conduct scientific tests.

Its a bit like asking someone how many times he hasn’t had an accident due to wearing a hi-viz jacket. I do however believe the vitamin is effective, as long as we treat the rest of our health seriously, as it is the robustness of our immune system as a whole, and not just a vitamin which might protect us from any viral attacks.

Kevin  

Kevin, D3  is a hormone that regulates several hundred genes, roughly 10% of all, its not "just a vitamin". Over 500 million years of evolution it has been involved in fine tuning our immune systems: innate, adaptive and surveillance. And most nations have populations that are seriously deficient. This thread has been about covid, but D3 is important, as you point out, for so many other aspects of our health long-term- see vitamindwiki. However its oldest role was in immunity, actions on bone, blood pressure, diabetes, cancers etc evolved later. Peter

Link to post
Share on other sites

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.

Guest
Reply to this topic...

×   Pasted as rich text.   Restore formatting

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.

Loading...
×
×
  • Create New...

Important Information

Please familiarise yourself with our Terms and Conditions. By using this site, you agree to the following: Terms of Use.