Peter Cobbold Posted July 6, 2020 Report Share Posted July 6, 2020 Another afternoon's work published: https://www.bmj.com/content/369/bmj.m2618/rr Peter Quote Link to post Share on other sites
barkerwilliams Posted July 13, 2020 Report Share Posted July 13, 2020 Yet more https://www.sciencedirect.com/science/article/pii/S2352364620300067?via%3Dihub#bb0965 Vitamin D deficiency and co-morbidities in COVID-19 patients – A fatal relationship? Alan Quote Link to post Share on other sites
Peter Cobbold Posted July 13, 2020 Report Share Posted July 13, 2020 4 hours ago, barkerwilliams said: Yet more https://www.sciencedirect.com/science/article/pii/S2352364620300067?via%3Dihub#bb0965 Vitamin D deficiency and co-morbidities in COVID-19 patients – A fatal relationship? Alan Complexities ! In the diagrams it is not obvious that renin acts to convert angiotensinogen to Ang1 - arrows are missing, but the legends state it. Difficult to follow, but comprhensive paper. Tks Alan, I had missed it. Peter Quote Link to post Share on other sites
PaulAnderson Posted July 14, 2020 Report Share Posted July 14, 2020 (edited) On 7/4/2020 at 4:09 PM, john.r.davies said: From a friend in the US, where people seem to be allowd to do their own thing, willy-nilly:   With last nights UK change in face covering policy for shops I’ve just heard a metropolitan police officer on the TV indicating that having shop keepers putting up signs like this ( no face covering, no entry) is the sort of things he wants to see happen.  He also wanted the use of face coverings in place now and not in 10 days time.   Paul Edited July 14, 2020 by PaulAnderson edited to change 'mask' to 'face covering' Quote Link to post Share on other sites
stuart Posted July 14, 2020 Report Share Posted July 14, 2020 Interesting article here https://medicalxpress.com/news/2020-07-complications-covid-von-willebrand-factor.html Stuart. Quote Link to post Share on other sites
Peter Cobbold Posted July 14, 2020 Report Share Posted July 14, 2020 2 hours ago, stuart said: Interesting article here https://medicalxpress.com/news/2020-07-complications-covid-von-willebrand-factor.html Stuart. Maybe ICU severity/mortality data will eventually show pts with von Willebrands disease ( too little of the factor) are spared. Or maybe they are in the large percentage of the population who never need a hospital, even asymptomatic. There is of course ! a D3 angle. Thrombomodulin is a anticoagulant whose production is promoted by D3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326442/ To me, the answer we need is why so many are known to have been infected but never showed signs, or only mild COVID. What are they doing right? One possibility is they were infected with a tiny amount of virus that their front line innate immunity dealt with easily, while hospitalised pts got larger droplets laden with virus. We cant tell. But masks have always seemed a very good idea , to me. D3 promotes that front line innate immunity by mouting a rapid secretion of antimicrobial peptides eg cathelicidin, defensins, in saliva, nasal secretions, tears, perhaps inactivating most of the virus witihn that fluid film before it can bind to cells, enter them and multiply. If D3 is deficient the peptide levels may be overwhelmed by viruses. Problem is, the science is very qualitative and asking questions at the level of virus/peptide ratios and fluxes is just not possible. We can see small rises in cathlicidin in saliva with D3-dosing but it is a long way from answering the "silent infection" question. https://ueaeprints.uea.ac.uk/id/eprint/53109/2/2015_He_et_al_The_effect_of_14_weeks_of_vitamin_D3_supplementation.pdf The "silent infecteds" hold the answer, but as far as I know, no science is being done on them. Peter    Quote Link to post Share on other sites
Bleednipple Posted July 15, 2020 Report Share Posted July 15, 2020 ...and in other news... Some problems fix themselves. Darwin Award candidate? https://metro.co.uk/2020/07/11/young-man-died-coronavirus-trying-catch-covid-party-prove-was-hoax-12976195/?ito=article.tablet.share.top.facebook&fbclid=IwAR3ut31XH-i6b0SqU-I0KSy16Z0rW6yXVCf2kruw4YC3K1kP6UzWp3mXJvQ Nigel Quote Link to post Share on other sites
john.r.davies Posted July 16, 2020 Report Share Posted July 16, 2020 It was the COVID Symptom Study that conformed the rumour that taste and smell disappearnce were an early sign of infection.  Now they have found that the virus can cause skin rashes. See: https://covid.joinzoe.com/post/skin-rash-covid Most common is "Covid Chilbains" on fingers and toes. You can contribute to the study. Go to the Apple App store (iPhone) or Google Play (Android) to down load the app. John Quote Link to post Share on other sites
barkerwilliams Posted July 16, 2020 Report Share Posted July 16, 2020 I also saw a report of an extreme adverse reaction at a hairdressers to a lady who had recovered from covid having her her dyed with the same chemicals that she always had had in the past, now sensitised to that product. Alan Quote Link to post Share on other sites
john.r.davies Posted July 16, 2020 Report Share Posted July 16, 2020 Please provide source, Alan.   Google cannot find anything like that. Doesn't mean I don't believe you, but where reported? Quote Link to post Share on other sites
Peter Cobbold Posted July 17, 2020 Report Share Posted July 17, 2020 The prospects for a vaccine do not look good: https://www.sfchronicle.com/health/article/With-coronavirus-antibodies-fading-fast-focus-15414533.php?cmpid=gsa-sfgate-result But- surprise, surprise - the evidence base for D3 has surged ahead in just a few months. This is the most comprehensive review I have seen and is very recent. https://www.researchgate.net/publication/342976453_A_Basic_Review_of_the_Preliminary_Evidence_that_Covid-19_Risk_and_Severity_is_Increased_in_Vitamin_D_Deficiency read the Conclusion first ! Maybe as vaccine hopes fade D3 will start to receive more interest. Peter Quote Link to post Share on other sites
Peter Cobbold Posted July 20, 2020 Report Share Posted July 20, 2020 I am picking up scientific vibes implicating selenium in replication of the corornavirus and severity of COVID. This ecoligical study form China shows a correlation between Se in hair and severity of COVID: https://academic.oup.com/ajcn/article/111/6/1297/5826147 The work I have just seen shows that the virus destroys Se-requiring enxymes such as Glutathione Peroxidase and that then allows the virus to replicate faster. These enzymes are long known to be promoted by D3. It may well turn out that deficiency of either D3 or Se favours the virus. I am assessing my Se intake from diet, as I already take 35% of RDA in a multivit. Data on RDAs are here: https://patient.info/doctor/selenium Peter Quote Link to post Share on other sites
little jim Posted July 21, 2020 Report Share Posted July 21, 2020 Brazil nuts on your porridge or weetbix is the nicest way to get your selenium. The daily intake is pretty low and one nut will do the trick. Have my doubts that it is really the cause of it all. Quote Link to post Share on other sites
Peter Cobbold Posted July 21, 2020 Report Share Posted July 21, 2020 (edited) 7 hours ago, little jim said: Brazil nuts on your porridge or weetbix is the nicest way to get your selenium. The daily intake is pretty low and one nut will do the trick. Have my doubts that it is really the cause of it all. We've been low on selenium for decades: https://www.cambridge.org/core/services/aop-cambridge-core/content/view/6FD904C1E7A36EE4D391606E184C9DB3/S0029665102000691a.pdf/argument_for_increasing_selenium_intake.pdf The ecological and cell data point to low activity of anti-oxidant enzymes utitlisng and recycling glutathione, thus allowing oxidative stress and apotosis ot create conditons more favourable for virus proliferatio **. D3 promotes production of those enzymes which also need Se to function. Better safe than sorry in my view. **Â https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3594240 Some forms of Se are safer than others, but the form in brazil nuts is not defined as far as I cna see https://link.springer.com/article/10.1007%2Fs42000-019-00125-5 Â Edited July 21, 2020 by Peter Cobbold Quote Link to post Share on other sites
Waldi Posted July 21, 2020 Report Share Posted July 21, 2020 The number of infected people is picking up here in Holland. Think the 2nd wave may come in 1-2 months if people don’t change their behaviour. Reproduction number increased to above 1. Our hope is in monitoring, tracking and voluntary isolation. What is the situation in the UK? Waldi  Quote Link to post Share on other sites
Peter Cobbold Posted July 21, 2020 Report Share Posted July 21, 2020 Waldi. UK numbers supposedly low, but without random testing no-one really knows. Deaths are at nadir, but that might disguise a greater preondernace of symptomless but infectious infecteds.  R number locally high in north manchester, and Leicester ( still in lockdown). I reckon on ther being a month maybe when it is safe fro family to visit for the day, outside,but when numbers rise again depends a lot on behaviours of the young ( below 50) who are unlikley to appear to be seriously affected. Its the oldies who need to keep well clear of youngsters for the indefinite future. Re-opening schools will threaten grannies at home. Vaccine form Oxford Uni under test in Brazil as in UK as too few catching the virus to test efficacy. The side-effects of even syptomless infections are being uncovered almost it seems e very week. The virus in my opinion is not to be messed with at any age, with or without D3+Se. I do wonder if BoJo is now putting the economy and jobs first, before the full impacts upon the nations health are known. Peter Peter  Quote Link to post Share on other sites
Waldi Posted July 22, 2020 Report Share Posted July 22, 2020 Hi Peter, we relaxed regulations for children under 12 in May, it is thought they do not infect others. Many people off course are still careful, and the numbers only reduced since (until last week). People aged 20-40 have the highest share in our infected persons. Currently only 3 people are hospitalised per day, this seems a small amount compared to March, when this was >100. Hope we get the spread under control, but I fear the same will happen here as in many other countries: numbers go up because people forget and behave less careful. Treatment options are improving for the most affected people on IC’s, so hope fatality rated will reduce. Have not seen statistics though, only fragmented news about better treatments. Waldi Quote Link to post Share on other sites
barkerwilliams Posted July 28, 2020 Report Share Posted July 28, 2020 on a lighter note.... I see reports of a cat with Coronavirus in UK https://www.bbc.co.uk/news/health-53552557 What I want to know is who had the nerve to shove those bl##dy swabs up the cats nose and throat - I bet it wasn't pleased! Alan  Quote Link to post Share on other sites
stillp Posted July 28, 2020 Report Share Posted July 28, 2020 Quote Link to post Share on other sites
SuzanneH Posted July 28, 2020 Report Share Posted July 28, 2020 Quote Link to post Share on other sites
foster461 Posted July 29, 2020 Report Share Posted July 29, 2020 They did a cat scan. Quote Link to post Share on other sites
Lebro Posted July 30, 2020 Report Share Posted July 30, 2020 Groan Quote Link to post Share on other sites
Ian Vincent Posted July 30, 2020 Report Share Posted July 30, 2020 On 7/22/2020 at 6:53 AM, Waldi said: Hi Peter, we relaxed regulations for children under 12 in May, it is thought they do not infect others. Many people off course are still careful, and the numbers only reduced since (until last week). People aged 20-40 have the highest share in our infected persons. Currently only 3 people are hospitalised per day, this seems a small amount compared to March, when this was >100. Hope we get the spread under control, but I fear the same will happen here as in many other countries: numbers go up because people forget and behave less careful. Treatment options are improving for the most affected people on IC’s, so hope fatality rated will reduce. Have not seen statistics though, only fragmented news about better treatments. Waldi What’s the science behind children under 12 not being infectious? Rgds Ian Quote Link to post Share on other sites
john.r.davies Posted July 30, 2020 Report Share Posted July 30, 2020 Isn't it more that kids are unlikely to understand why they must wear the mask, to object to it, to take it off, to fiddle with the mask (don't touch it! Dispose of it when you take it ioff, or wash right away!).  Not that many adults complying just as poorly!   I saw someone at the supermarket use their gloved hands (!!) to take the maks off and adjust their earbuds!   And the famous online video of the person removing a mask to lick their gloves to leaf through papers!!!! John Quote Link to post Share on other sites
Peter Cobbold Posted July 30, 2020 Report Share Posted July 30, 2020 (edited) 3 hours ago, Ian Vincent said: What’s the science behind children under 12 not being infectious? Rgds Ian They dont seem to contribute much to the spread of the virus within a population, but do carry a viral load so can be infectious: https://onlinelibrary.wiley.com/doi/epdf/10.1111/apa.15371 So a politician or CMO worried about the big picture will open schools with rather little concern. But granny at home should worry every time grandsprogs come back from school. Epidemiologists deal with numbers, granny is unique - a difference in risk perception. Most individuals, myself included, do not think like epidemiologists. To me, a child infecting granny is a disaster. But such events may not contribute much to spread, especially in societies where granny does not live with her family. I see the extended families of some ethnicities with several generations in one house, putting their elderly at high risk from opening schools. Peter Edited July 30, 2020 by Peter Cobbold Quote Link to post Share on other sites
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