Jump to content

Recommended Posts

  • Replies 1.9k
  • Created
  • Last Reply

Top Posters In This Topic

Top Posters In This Topic

Popular Posts

HELP THE NHS ~ I've let my adjoining empty house (fully furnished) to four NHS nurses free of charge during this National Emergency. We have a very large General Hospital at the top of the r

Very very Harsh Geko. I see a man, in an unenviable position, doing his utmost to balance the impossible tasks of trying to control the spread of a new novel virus - for which there is no treatme

By the book...

Posted Images

4 hours ago, barkerwilliams said:

Yet more

https://www.sciencedirect.com/science/article/pii/S2352364620300067?via%3Dihub#bb0965

Vitamin D deficiency and co-morbidities in COVID-19 patients – A fatal relationship?

Alan

Complexities ! In the diagrams it is not obvious that renin acts to convert angiotensinogen to Ang1 - arrows are missing, but the legends state it.  Difficult to follow, but comprhensive paper.

Tks Alan, I had missed it.

Peter

Link to post
Share on other sites
On 7/4/2020 at 4:09 PM, john.r.davies said:

From a friend in the US, where people seem to be allowd to do their own thing, willy-nilly:

 

 

laconic.png

With last nights UK change in face covering policy for shops I’ve just heard a metropolitan police officer on the TV indicating that having shop keepers putting up signs like this ( no face covering, no entry) is the sort of things he wants to see happen.  He also wanted the use of face coverings in place now and not in 10 days time.  
 

Paul

Edited by PaulAnderson
edited to change 'mask' to 'face covering'
Link to post
Share on other sites
2 hours ago, stuart said:

Maybe ICU severity/mortality data will eventually show pts with von Willebrands disease ( too little of the factor) are spared. Or maybe they are in the large percentage of the population who never need a hospital, even asymptomatic.

There is of course ! a D3 angle. Thrombomodulin is a anticoagulant whose production is promoted by D3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326442/

To me, the answer we need is why so many are known to have been infected but never showed signs, or only mild COVID. What are they doing right?  One possibility is they were infected with a tiny amount of virus that their front line innate immunity dealt with easily, while hospitalised pts got larger droplets laden with virus. We cant tell. But masks have always seemed a very good idea , to me.

D3 promotes that front line innate immunity by mouting a rapid secretion of antimicrobial peptides eg cathelicidin, defensins, in saliva, nasal secretions, tears, perhaps inactivating most of the virus witihn that fluid film before it can bind to cells, enter them and multiply. If D3 is deficient the peptide levels may be overwhelmed by viruses. Problem is, the science is very qualitative and asking questions at the level of virus/peptide ratios and fluxes is just not possible. We can see small rises in cathlicidin in saliva with D3-dosing but it is a long way from answering the "silent infection" question.

https://ueaeprints.uea.ac.uk/id/eprint/53109/2/2015_He_et_al_The_effect_of_14_weeks_of_vitamin_D3_supplementation.pdf

The "silent infecteds" hold the answer, but as far as I know, no science is being done on them.

Peter

 

 

 

Link to post
Share on other sites

It was the COVID Symptom Study that conformed the rumour that taste and smell disappearnce were an early sign of infection.   Now they have found that the virus can cause skin rashes.  See: https://covid.joinzoe.com/post/skin-rash-covid

Most common is "Covid Chilbains" on fingers and toes.

You can contribute to the study.  Go to the Apple App store (iPhone) or Google Play (Android) to down load the app.

John

Link to post
Share on other sites

I also saw a report of an extreme adverse reaction at a hairdressers to a lady who had recovered from covid having her her dyed with the same chemicals that she always had had in the past, now sensitised to that product.

Alan

Link to post
Share on other sites

The prospects for a  vaccine do not look good:

https://www.sfchronicle.com/health/article/With-coronavirus-antibodies-fading-fast-focus-15414533.php?cmpid=gsa-sfgate-result

But- surprise, surprise - the evidence base for D3 has surged ahead in just a few months. This is the most comprehensive review I have seen and is very recent. https://www.researchgate.net/publication/342976453_A_Basic_Review_of_the_Preliminary_Evidence_that_Covid-19_Risk_and_Severity_is_Increased_in_Vitamin_D_Deficiency

read the Conclusion first !

Maybe as vaccine hopes fade D3 will start to receive more interest.

Peter

Link to post
Share on other sites

I am picking up scientific vibes implicating selenium in replication of the corornavirus and severity of COVID. This ecoligical study form China shows a correlation between Se in hair and severity of COVID:

https://academic.oup.com/ajcn/article/111/6/1297/5826147

The work I have just seen shows that the virus destroys Se-requiring enxymes such as Glutathione Peroxidase and that then allows the virus to replicate faster. These enzymes are long known to be promoted by D3.

It may well turn out that  deficiency of either D3 or Se favours the virus. I am assessing my Se intake from diet, as I already take 35% of RDA in a multivit.  Data on RDAs are here: https://patient.info/doctor/selenium

Peter

Link to post
Share on other sites
7 hours ago, little jim said:

Brazil nuts on your porridge or weetbix is the nicest way to get your selenium. The daily intake is pretty low and one nut will do the trick.

Have my doubts that it is really the cause of it all.

We've been low on selenium for decades: https://www.cambridge.org/core/services/aop-cambridge-core/content/view/6FD904C1E7A36EE4D391606E184C9DB3/S0029665102000691a.pdf/argument_for_increasing_selenium_intake.pdf

The ecological and cell data point to low activity of anti-oxidant enzymes utitlisng and recycling glutathione, thus allowing oxidative stress and apotosis ot create conditons more favourable for virus proliferatio **. D3 promotes production of those enzymes which also need Se to function. Better safe than sorry in my view.

**  https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3594240

Some forms of Se are safer than others, but the form in brazil nuts is not defined as far as I cna see

https://link.springer.com/article/10.1007%2Fs42000-019-00125-5

 

Edited by Peter Cobbold
Link to post
Share on other sites

The number of infected people is picking up here in Holland. Think the 2nd wave may come in 1-2 months if people don’t change their behaviour. Reproduction number increased to above 1.
Our hope is in monitoring, tracking and voluntary isolation.
What is the situation in the UK?

Waldi

 

Link to post
Share on other sites

Waldi. UK numbers supposedly low, but without random testing no-one really knows. Deaths are at nadir, but that might disguise a greater preondernace of symptomless but infectious infecteds.   R number locally high in north manchester, and Leicester ( still in lockdown).  I reckon on ther being a month maybe when it is safe fro family to visit for  the day, outside,but when numbers rise again depends a lot on behaviours of the young ( below 50) who  are unlikley to appear to be seriously affected. Its the oldies who need to keep well clear of youngsters for the indefinite future. Re-opening schools will threaten grannies at home.

Vaccine form Oxford Uni under test in Brazil as in UK as too few catching the virus to test efficacy.

The side-effects of even syptomless infections are being uncovered almost it seems e very week. The virus in my opinion is not to be messed with at any age, with or without D3+Se. I do wonder if BoJo is now putting the economy and jobs first, before the full impacts upon the nations health are known.

Peter

Peter

 

Link to post
Share on other sites

Hi Peter,

we relaxed regulations for children under 12 in May, it is thought they do not infect others. Many people off course are still careful, and the numbers only reduced since (until last week). 
People aged 20-40 have the highest share in our infected persons.

Currently only 3 people are hospitalised per day, this seems a small amount compared to March, when this was >100.
Hope we get the spread under control, but I fear the same will happen here as in many other countries: numbers go up because people forget and behave less careful.

Treatment options are improving for the most affected people on IC’s, so hope fatality rated will reduce. Have not seen statistics though, only fragmented news about better treatments.

Waldi

Link to post
Share on other sites
On 7/22/2020 at 6:53 AM, Waldi said:

Hi Peter,

we relaxed regulations for children under 12 in May, it is thought they do not infect others. Many people off course are still careful, and the numbers only reduced since (until last week). 
People aged 20-40 have the highest share in our infected persons.

Currently only 3 people are hospitalised per day, this seems a small amount compared to March, when this was >100.
Hope we get the spread under control, but I fear the same will happen here as in many other countries: numbers go up because people forget and behave less careful.

Treatment options are improving for the most affected people on IC’s, so hope fatality rated will reduce. Have not seen statistics though, only fragmented news about better treatments.

Waldi

What’s the science behind children under 12 not being infectious?

Rgds Ian

Link to post
Share on other sites

Isn't it more that kids are unlikely to understand why they must wear the mask, to object to it, to take it off, to fiddle with the mask (don't touch it!  Dispose of it when you take it ioff, or wash right away!).   Not that many adults complying just as poorly!      I saw someone at the supermarket use their gloved hands (!!) to take the maks off and adjust their earbuds!     And the famous online video of the person removing a mask to lick their gloves to leaf through papers!!!!

John

Link to post
Share on other sites
3 hours ago, Ian Vincent said:

What’s the science behind children under 12 not being infectious?

Rgds Ian

They dont seem to contribute much to the spread of the virus within a population, but do carry a viral load so can be infectious:

https://onlinelibrary.wiley.com/doi/epdf/10.1111/apa.15371

So a politician or CMO worried about the big picture will open schools with rather little concern. But granny at home should worry every time grandsprogs come back from school. 

Epidemiologists deal with numbers, granny is unique -  a difference in risk perception. Most individuals, myself included, do not think like epidemiologists. To me, a child infecting granny is a disaster. But such events may not contribute much to spread, especially in societies where granny  does not  live with her family. I see the extended families of some ethnicities with  several generations in one house, putting their elderly at high risk from opening  schools.

Peter

Edited by Peter Cobbold
Link to post
Share on other sites

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.

Guest
Reply to this topic...

×   Pasted as rich text.   Restore formatting

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.

Loading...
×
×
  • Create New...

Important Information

Please familiarise yourself with our Terms and Conditions. By using this site, you agree to the following: Terms of Use.